Leta 1970 so najboljše prijateljice Roberta, Teeny, Samantha in Chrissy dopolnile dvanajst let. Takrat so si obljubile, da si bodo vedno stale ob strani. Po petindvajsetih letih se spet srečajo v podobah Rosie O'Donnell, Melanie Griffith, Demi Moore in Rite Wilson. Roberta je odrasla v zdravnico, Teeny v igralko, Samantha v pisateljico, Chrissy pa v gospodinjo in bodočo mamico. Spomini jih kmalu popeljejo v otroške dni, ko so se začele razvijati v osebnosti, kakršne so danes.
Roberta, Teeny, Samantha and Chrissy have been busy growing up, but they always remembered the promise they made to be there for each other. Now they're together again to relive the greatest summer of their lives.