Možje X so mutanti. Človeška bitja, ki so genetsko mutirala in dobila nadčloveške sposobnosti. V svetu, kjer je vse več sovraštva in predsodkov, so izobčenci, ki se jih ljudje bojijo in jih prezirajo Pod vodstvom profesorja Charlesa Xavierja so se naučili obvladovati in usmerjati svoje moči v dobro človeštva. Zapletli so se v bitko s profesorjevim nekdanjim prijateljem Magnetom, ki je bil prepričan, da ljudje in mutanti ne morejo živeti v sožitju. A sedaj Možje X dobijo novega sovražnika: zlobnega generala Williama Strykerja, ki napade Xavierjevo šolo in resno ogrozi obstoj človeštva. Mutanti in ljudje morajo zato v boju proti Strykerju združiti moči.
Several months have passed since The X-Men defeated Magneto and imprisoned him in a seemingly impregnable plastic chamber. One day, a mutant by the name of Nightcrawler infiltrates the White House and attempts to assassinate the president, setting off a chain reaction of anti-mutant measures by the government. Meanwhile, Logan is trying to discover his past. As scientist named William Stryker discovers Professor X's secret school and Cerebro, Magneto's partner, Mystique, is planning to break her leader out of prison. But when Professor X's school is attacked by Stryker's forces, Logan, Rogue, Iceman and a few are lucky to escape. Those who remain meet in Boston, where they form an uneasy alliance with Magneto to stop Stryker and rescue Professor X.
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