Dr. Kimble je priznan kirurg, ki s svojo lepo ženo Helen živi v najbolj bogati soseski daleč naokoli. Njegovo življenje je srečno vse do noči Heleninega umora. Zanj pa je Kimble po krivem obsojen na dosmrtno ječo. Uspe mu pobegniti, vendar naenkrat postane človek brez imena, brez doma, brez prijateljev in stalno na begu. Kljub temu je trdno odločen, da bo našel ženinega morilca. Za petami mu je nepopustljivi vladni agent Samuel Gerard, ki ima na razpolago ekipo zagrizenih sodelavcev.
A well respected Chicago surgeon Dr. Richard Kimble has found out that his wife, Helen, has been murdered ferociously in her own home. The police found Kimble and accused him of the murder. Then, Kimble (without Justifiable Reason) was tried, convicted, and sentenced to death. However, on the way to prison, Kimble's transport crashed. Kimble escapes and is now on the run. Deputy Samuel Gerard from Chicago takes charge of the chase of Kimble. Meanwhile, Kimble takes up his own investigation to find who really killed his wife, and to lure Gerard and his team into it as well.