Nevrotični Felix je obseden s čistočo in redom, njegovemu prijatelju Oscarju pa je prav malo mar za redoljubnost. Pa tudi sicer sta si prijatelja različna kot noč in dan, zato se stalno zapletata v številne smešne pripetljaje. Tokrat se z avtomobilom odpravljata na poroko Felixove hčerke in Oscarjevega sina. Med potjo se izgubita, uničita avto, postaneta štoparja in se zapleteta v noro dogodivščino.
It has been seventeen years now since Oscar and Felix saw each other for the last time. Oscar is living in Florida, Felix in New York. One day, Oscar is called by his son Brucey who invites him to his wedding to Felix' daughter Hannah next Sunday in California. Oscar and Felix meet again at Los Angeles International Airport and take a rental car in order to go to San Malina for the wedding. The trip develops into an odyssey, starting with Oscar forgetting Felix' suitcase at the Budget station, going over to the complete loss of the directions (and the car), several difficulties with the police, a dead person, a toupee, underwear and revenge-hungry Cowboys and ending up with Felix meeting the "one and only" woman. But the wedding has to be reached on time.