John Constantine je bil v peklu in prišel nazaj. Rodil se je s sposobnostjo, da vidi angele in demone, ki se sprehajajo po Zemlji v človeški preobleki. Da bi pobegnil pred nezaželenimi videnji, je poskusil storiti samomor. Proti njegovi volji mu je bilo življenje zopet povrnjeno, zato zdaj spet tlači Zemljo. Da bi se odkupil za svoj greh, se bori proti demonom, ki jih pošilja nazaj v pekel. Njegovo zagrenjeno življenje zmoti policistka Angela Dodson, ki potrebuje njegovo pomoč. Njena sestra dvojčica je prav tako storila samomor in se tako zapisala večni pogubi. Constantine kmalu ugotovi, da se pripravlja spopad med dobrim in zlim, kot ga še ni bilo.
John Constantine is approached by Det. Angela Dodson who needs his help to prove that her twin sister Isabel's death was not a suicide. The dead woman was a devout Catholic and Angela refuses to accept she would have taken her own life. She's asked Constantine for help because he has a reputation for dealing with the mystical. In fact, he is a demon hunter whose sole purpose on Earth is to send demons back to the nether regions. John himself has been to Hell and knows that he is destined to return there on his death - but hopes his good deeds may find him a place in Heaven. As he looks into Isabel's death, he realizes demons are trying to break through to the human world, and his battles lead him into a direct conflict with Satan.