Film, posnet po priljubljeni videoigrici, se godi v daljni prihodnosti. Znanstveniki so v sodelovanju z vojsko na Marsu ustanovili raziskovalno postajo. Ko nekega dne izgubijo stik z njo, nihče ne ve, kaj se je zgodilo. Tja pošljejo posebno enoto, ki jo vodita marinca Sarge in Reaper, da bi ugotovila, kaj se dogaja. Marinca hitro ugotovita, da so se zaradi eksperimentov na raziskovalni postaji odprla vrata pekla, skozi katera so prišli razni demoni in druge pošasti, ki sedaj grozijo s popolnim opustošenjem.
Something has gone wrong at a remote scientific research station on Mars. All research has ceased. Communication has failed. And the messages that do get through are less than comforting. It's a level 5 quarantine and the only souls allowed in or out are the Rapid Response Tactical Squad - hardened Marines armed to the teeth with enough firepower to neutralize the enemy...or so they think.