Po ugrizu volkodlaka se spremeni življenje trem mladostnikom, ki morajo zdaj ubiti pošast, da se ne bi tudi sami spremenili v volkodlake.
Ellie has been taking care of her younger brother Jimmy since their parents death. One night after picking him up from a party they are involved in a car accident on Mullholland Drive. While trying to rescue a woman from the other car a creature attacks and kills her, also injuring both Ellie and Jimmy. After some research Jimmy realizes the creature could only have been a werewolf.