Film temelji na resničnih dogodkih.V poznih šestdesetih letih množični morilec, znan pod imenom Zodiak, mori v San Franciscu. Detektivi si prizadevajo, da bi ga ustavili in preprečili nove žrtve.
THE ZODIAC takes a different look at the famous Zodiac Killer case from other screen treatments of the murders. More than a simple crime story, the film is an emotional thriller focusing on the murders' impact on victims, their families and the wider community. The film follows a police detective and his son who become obsessed with the murders and endanger their family in the process.