Potem ko so pred mnogimi leti bogovi dobili bitko proti Titanom, zemlji grozi nova nevarnost. Kralj Hiperion, ki hlepi po moči in prevladi, s svojo vojsko požiga Grčijo in pobija ljudi v želji, da bi našel mogočno legendarno orožje in z njim osvobodil Titane. Ti so že dolga stoletja zaprti na gori Tartar in potrpežljivo čakajo na priložnost za maščevanje. Ker se bogovi ne smejo vpletati v človeske vojne, Zevs na skrivaj izbere mladeniča Tezeja in ga obdari s posebnimi močmi, tako da se je s svojo uporniško vojsko sposoben upreti Hiperionu in njegovi vojski.
Eons after the Gods won their mythic struggle against the Titans, a new evil threatens the land. Mad with power, King Hyperion (Mickey Rourke) has declared war against humanity. Amassing a bloodthirsty army of soldiers disfigured by his own hand, Hyperion has scorched Greece in search of the legendary Epirus Bow, a weapon of unimaginable power forged in the heavens by Ares. Only he who possesses this bow can unleash the Titans, who have been imprisoned deep within the walls of Mount Tartaros since the dawn of time and thirst for revenge. In the king's hands, the bow would rain destruction upon mankind and annihilate the Gods. But ancient law dictates the Gods must not intervene in man's conflict. They remain powerless to stop Hyperion...until a peasant named Theseus (Henry Cavill) comes forth as their only hope. Secretly chosen by Zeus, Theseus must save his people from Hyperion and his hordes. Rallying a band of fellow outsiders - including visionary priestess Phaedra (Freida Pinto) and cunning slave Stavros (Stephen Dorff) - one hero will lead the uprising, or watch his homeland fall into ruin and his Gods vanish into legend.