Glenn Fitzgerald je mladi preprodajalec marihuane in bobnar v rock skupini. Ko ga prijatelji vržejo iz benda, se posveti svoji obstranski dejavnosti, da bi vzdrževal svojo punco Monico, ter se začne družiti z uporniškim sosedom Jimmyjem. Nekega dne Glenna skoraj razkrinkajo pri preprodaji nelegalnih substanc, zato se odloči zbežati od doma, da bi se izognil aretaciji. Na begu se mu pridruži tudi Jimmy, ki želi zbežati pred svojim napornim očetom.
High Road showcases a totally improvised script about Glenn "Fitz" Fitzgerald (James Pumphery), a young man whose loyalties are split among his band, his girlfriend Monica (Abby Elliott) and selling weed. After his band breaks up, Fitz finds himself dealing pot out of his garage and bonding with a rebellious 16-year-old Jimmy (Dylan O'Brien). As his former band mates (Zach Woods, Matt L. Jones, Lizzy Caplan) find success and one of his drug deals goes awry, Fitz and Jimmy hit the road. Amid guns, broken bones, sassy cabbies, rude hookers, and a suspicious doctor (Horatio Sanz), Fitz has to navigate their way to safety-and he doesn't even know about the surprise Monica has in store for him back home!