Ameriški vojak Steve Rogers se udeleži skrivnega vojaškega programa, ki mu vtisne nadčloveško moč; z novimi zmožnostmi se zoperstavi zlobnemu Rdeči lobanji. Akcijsiki triler je posnet po stripu.Leta 1941 svet pretresa vojna. Potem ko se je večkrat skušal prijaviti v vojsko, da bi skupaj z rojaki sodeloval pri zavezniških operacijah, mladega in suhljatega Steva Rogersa (Chris Evans) sprejmejo v skrivni program, ki ga spremeni v super-junaka, znanega kot Stotnik Amerika. Z novo pridobljenimi sposobnostmi združi moči s prijateljem Buckyjem Barnesom (Sebastian Stan) in samozavestno Peggy Carter (Hayley Atwell) pod poveljstvom polkovnika Chesterja Phillipsa (Tommy Lee Jones) – da bi se zoperstavili zlobni organizaciji HYDRA oz. nacističnemu oddelku za razvoj skrivne tehnologije pod vodstvom neusmiljenega Rdeče lobanje (Hugo Weaving).
It is 1942, America has entered World War II, and sickly but determined Steve Rogers is frustrated at being rejected yet again for military service. Everything changes when Dr. Erskine recruits him for the secret Project Rebirth. Proving his extraordinary courage, wits and conscience, Rogers undergoes the experiment and his weak body is suddenly enhanced into the maximum human potential. When Dr. Erskine is then immediately assassinated by an agent of Nazi Germany's secret HYDRA research department (headed by Johann Schmidt, a.k.a. the Red Skull), Rogers is left as a unique man who is initially misused as a propaganda mascot; however, when his comrades need him, Rogers goes on a successful adventure that truly makes him Captain America, and his war against Schmidt begins.