Abraham Lincoln je bil pri devetih letih priča umora svoje matere Nancy, ki jo je ubil vampir Jack Barts. Ko se devet let kasneje poskuša maščevati Bartsu, Lincoln za las uide smrti po zaslugi lovca na vampirje Henryja Sturgessa, ki mladeniča vzame pod svoje okrilje in ga nauči bojevati se proti vampirjem. Leta kasneje se Lincoln preseli v Springfield, kjer podnevi dela v trgovini Joshue Speeda, ponoči pa pobija vampirje. Toda s tem se Lincolnovo življenje v vlogi lovca na vampirje šele dobro začne. Ko desetletja kasneje postane predsednik ZDA, mora Lincoln pred novo vampirsko nevarnostjo rešiti konfederacijske sile in za vedno končati ameriško državljansko vojno.
At the age of 9, Abraham Lincoln witnesses his mother being killed by a vampire, Jack Barts. Some 10 years later, he unsuccessfully tries to eliminate Barts but in the process makes the acquaintance of Henry Sturgess who teaches him how to fight and what is required to kill a vampire. The quid pro quo is that Abe will kill only those vampires that Henry directs him to. Abe relocates to Springfield where he gets a job as a store clerk while he studies the law and kills vampires by night. He also meets and eventually marries the pretty Mary Todd. Many years later as President of the United States, he comes to realize that vampires are fighting with the Confederate forces. As a result he mounts his own campaign to defeat them.