Film 43 je najbolj nesramno zabaven in politično nekorekten film, ki ne pozna meja. Različne zgodbe številnih ljudi, večinoma povsem neprilagojenih običajnim družbenim standardom, se prepletejo v zabaven vihar besednih obračunov in bolečih fizičnih soočenj, ki se končajo v kaosu.
Ineffectual, 'has-been' film-maker (Dennis Quaid) swindles his way into an interview with a film executive (Greg Kinnear) in order to pitch an outrageous and controversial comedy manuscript. After pitching the first of his thirteen offbeat fables, the dejected artist forces the rest of his disjointed allegory on the executive at gunpoint. He tells stories of a woman on a blind date with a man who has testicles growing from his neck, in another a smitten woman offers her neck to her boyfriend to 'poop' on -as a sign of commitment and love. In yet another two parents take home-schooling to a whole new level of indecency, striving to give their isolated teenage son all the 'regular' torment and humiliation of puberty by bullying, peer-pressuring and even seducing him themselves. An off-beat, elephant-in-the-room type film.