Goody in Stacy obožujeta nočno življenje in divje zabave, medtem ko čuvata veliko skrivnost. Dekleti sta moderni vampirki. Prijateljicama kmalu začne povzročati preglavice ljubezen, saj se Stacy nepričakovano zaljubi v sina lovca na vampirje, medtem ko Goody sreča svojega princa na belem konju. Tako se znajdeta pred težko odločitvijo: se bosta odpovedali večni mladosti in dali priložnost ljubezni?
In Manhattan, the vampires Goody and Stacy share an apartment and work and study in the night-shift. Goody was turned in vampire in 1840 by the evil Cisserus, who turned Stacy in the 90s, and they became best friends but Goody never told her real age to her friend. They only drink mice blood and refuse to drink human blood, and they go together to the Vampire Anonymous. Stacy falls in love with her classmate Joey, and soon she learns that he is the son of the vampire slayer Dr. Van Helsing. Meanwhile, Goody meets her former passion, Danny, in the hospital where his wife is terminal. When Stacy gets pregnant, Goody knows that the only way that the child can survive is killing Cisserus, since they would revert to their human ages. But nobody knows where her lair is.