Obsojeni morilec Carl Lucas, znan tudi kot Frankenstein, je glavna zvezda med dirkači v nasilni različici športne dirke na življenje ali smrt. Od glavne nagrade ga loči le še ena zmaga, kar pomeni svobodo zanj in njegovo ekipo. Dirka se tokrat seli v puščavo Kalahari, kjer se bo moral Frankenstein v lovu za peto zaporedno zmago soočiti z novimi sotekmovalci in tolpami domačinov. Zaradi nepredvidljivih okoliščin bo naloga vse prej kot lahka.
Convicted cop-killer Carl Lucas, aka Frankenstein, is a superstar driver in the brutal prison yard demolition derby known as Death Race. Only one victory away from winning freedom for himself and his pit crew, Lucas is plunged into an all-new competition more vicious than anything he has experienced before. Pitted against his most ruthless adversaries ever, Lucas fights to keep himself and his team alive in a race in South Africa's infernal Kalahari Desert. With powerful forces at work behind the scenes to ensure his defeat, will Lucas' determination to win at all costs mean the end of the road for him?