Na robu prve svetovne vojne mlada ameriška medicinska sestra Lillie odpotuje z medicinskimi pripomočki v oddaljeno misijonsko bolnišnico v Otomanskem imperiju. Med potovanjem se začne zaljubljati v svojega spremljevalca Ismaila, otomanskega poročnika. Toda ko svet tone v vojno, se Lillie znajde razpeta med misijonom in svojo ljubeznijo do Ismaila.
A strong-willed young woman, who, frustrated by on-going injustice at home, leaves the U.S. after meeting Jude, an American doctor who runs a remote medical mission within the Ottoman Empire. A world both exotic and dangerous, and on the brink of what is about to become World War I. There, she finds her loyalty to Jude and the mission's founder tested when she falls in love with their perceived enemy, a Lieutenant in the Ottoman Imperial Army. Now, with invading army forces at their doorstep, and the world about to plunge into all-out war, she must make a decision if she wants to be what other people want her to be, or to be herself.